NIST 800-171
U.S. framework protecting CUI confidentiality in nonfederal systems
ISO 22301
International standard for business continuity management systems.
Quick Verdict
NIST 800-171 protects CUI confidentiality for federal contractors via security controls, while ISO 22301 builds business continuity resilience for all organizations through BCMS. Companies adopt NIST for DoD compliance and ISO for disruption recovery and certification.
NIST 800-171
NIST SP 800-171 Rev 3: Protecting CUI in Nonfederal Systems
Key Features
- Tailored SP 800-53 controls for nonfederal CUI protection
- SSP and POA&M required for implementation documentation
- Scoped to CUI-processing components and enclaves
- Mandatory via DFARS for DoD contractors handling CDI
- Assessment procedures using examine-interview-test methods
ISO 22301
ISO 22301:2019 Business continuity management systems Requirements
Key Features
- PDCA cycle for continual BCMS improvement
- Business Impact Analysis (BIA) and risk assessment
- Leadership commitment and BCMS policy requirements
- Operational planning with testing and exercises
- Seamless integration with ISO 27001 and others
Detailed Analysis
A comprehensive look at the specific requirements, scope, and impact of each standard.
NIST 800-171 Details
What It Is
NIST SP 800-171 Revision 3 is a U.S. government framework providing security requirements to protect Controlled Unclassified Information (CUI) confidentiality in nonfederal systems. Tailored from SP 800-53 Moderate baseline, it applies risk-based controls to components processing, storing, or transmitting CUI, emphasizing scoped enclaves.
Key Components
- 97 requirements across 17 families (e.g., Access Control, Audit, Supply Chain Risk Management).
- Built on FIPS 200 and SP 800-53 principles.
- Requires System Security Plan (SSP) and Plan of Action and Milestones (POA&M).
- Companion SP 800-171A r3 for examine/interview/test assessments.
Why Organizations Use It
- Mandatory for DoD contractors via DFARS 252.204-7012 safeguarding CDI.
- Enables contract eligibility, CMMC Level 2 compliance, risk reduction.
- Builds stakeholder trust, competitive edge in federal supply chains.
Implementation Overview
Phased approach: scope CUI boundaries, gap analysis, implement controls (MFA, SIEM), document SSP/POA&M. Applies to contractors of all sizes; audits via self or C3PAO. Timelines 6-36 months depending on scale.
ISO 22301 Details
What It Is
ISO 22301:2019 is the international standard titled Security and resilience — Business continuity management systems — Requirements. It provides a certifiable framework for establishing, implementing, maintaining, and improving a Business Continuity Management System (BCMS). Its primary purpose is to enhance organizational resilience against disruptions like cyberattacks, pandemics, and natural disasters through a risk-based, PDCA (Plan-Do-Check-Act) approach.
Key Components
- 10 clauses structured around Annex SL high-level structure (Clauses 4-10 core).
- Key pillars: context analysis (Clause 4), leadership commitment (5), planning with BIA/risk assessment (6), support/resources (7), operations/testing (8), evaluation/audits (9), improvement (10).
- No fixed controls; flexible, tailored requirements.
- Certification valid 3 years with annual surveillance audits.
Why Organizations Use It
Drives resilience, reduces downtime/financial losses, ensures regulatory compliance (e.g., NIS Directive), boosts stakeholder trust/reputation, and offers competitive edges like procurement advantages. Enhances risk management and integrates with ISO 27001.
Implementation Overview
Phased approach: gap analysis, BIA, policy development, training, testing, audits. Applicable to all sizes/sectors globally. Certification via two-stage process (6-8 weeks readiness/effectiveness). Tools accelerate to 60 days.
Key Differences
| Aspect | NIST 800-171 | ISO 22301 |
|---|---|---|
| Scope | CUI confidentiality in nonfederal systems | Business continuity management system resilience |
| Industry | DoD contractors, federal supply chains | All sectors worldwide, any size |
| Nature | Recommended security requirements, contractual | Certifiable management system standard |
| Testing | Examine/interview/test per 800-171A | Tabletop exercises, audits, simulations |
| Penalties | Contract ineligibility, DFARS enforcement | Loss of certification, no legal penalties |
Scope
Industry
Nature
Testing
Penalties
Frequently Asked Questions
Common questions about NIST 800-171 and ISO 22301
NIST 800-171 FAQ
ISO 22301 FAQ
You Might also be Interested in These Articles...

HITRUST CSF MyCSF Platform Deep Dive: Automating Evidence Collection for Continuous R2 Renewal in Multi-Regulated Environments 2025
Unpack MyCSF's AI features for HITRUST CSF: automate evidence tagging, maturity scoring & monitoring for R2 renewals amid 2025 regs. CISOs in healthcare/fintech

PDPA Cross-Border Transfer Rules Decoded: Singapore, Thailand, and Taiwan Mechanisms Compared with Practical Implementation Templates
Decode PDPA cross-border transfers for Singapore, Thailand, Taiwan. Statutory excerpts, approved mechanisms, SCC templates. Harmonize with GDPR, navigate exempt

Asset-Backed Issuers and SEC Cybersecurity Rules: Applicability, Disclosures, and Compliance Roadmap
How SEC cybersecurity rules apply to asset-backed issuers (ABS): Form 10-D disclosures, ABS-EE risk management, Inline XBRL tagging, exemptions. Roadmap for tru
Run Maturity Assessments with GRADUM
Transform your compliance journey with our AI-powered assessment platform
Assess your organization's maturity across multiple standards and regulations including ISO 27001, DORA, NIS2, NIST, GDPR, and hundreds more. Get actionable insights and track your progress with collaborative, AI-powered evaluations.
Check out these other Gradum.io Standards Comparison Pages
ISO 17025 vs C-TPAT
Compare ISO 17025 lab accreditation vs C-TPAT supply chain security: competence, impartiality & validation meet risk-based trusted trader benefits. Optimize compliance now!
NIST 800-53 vs AS9120B
Compare NIST 800-53 vs AS9120B: Federal security meets aerospace quality. Tailor controls for supply chains, privacy & risk. Optimize compliance now!
AEO vs ISO 37301
Compare AEO vs ISO 37301: Customs facilitation (AEO) or full CMS standard? Discover differences in security, compliance pillars, benefits & implementation. Boost trade efficiency now!